I did it twice the first time with 1 other guy on arcade and the next time on my own with bots, they take care mostly of the guards you pretty much can concentrate on the queen and shoot the shriekers down. I did it with just super reload mutator it helps kill guards mega quick if the bots miss them and the shriekers blow up with a couple of bullets. It takes a few tries but it can be done. Don't bother with the instagib melee or you will end up rushing the guards and getting wasted. Infinite ammo would help but there are ammo crates you can pick up just as the queen jumps on the tower refill your ammo then shoot the bitch off. This is assuming you got past the first checkpoint.
If you still aint got it I will help but it must be arcade I can take care of the guards/shriekers so you can just shoot the queen, it doesn't take very long with super reload the bullets really do damage!